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Literature summary extracted from

  • Wang, T.; Yang, J.; Qiao, J.; Liu, J.; Guo, X.; Ye, Z.
    Activity and expression of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate urolithiasis (2010), Urol. Int., 85, 94-99.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.90 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.90 epithelial cell
-
 Homo sapiens
-
4.1.1.90 renal tubule
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 gamma-glutamyl carboxylase
-
 Homo sapiens
4.1.1.90 GGCX
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.1.1.90 Homo sapiens GGCX mRNA in the urolithiasic group is lower than that in the normal control group, which is on average 7.86fold underexpressed in the urolithiasic group compared to the normal control group. Protein expression of GGCX in the urolithiasic group is weaker than that in the control groups down

General Information

EC Number General Information Comment Organism
4.1.1.90 physiological function relevance between the defect of GGCX and urolithasis. Decreased activity and production of GGCX between calcium oxalate urolithiasis patients and control patients. GGCX may play an important role in the formation of calcium oxalate. The decreased expression of GGCX may lead to the defect of activity, and may result in the declined ability of calcium oxalate of urinary prothrombin fragment 1 Homo sapiens